Background: Globally, 1 in 6 people experience infertility, affecting approximately 182 million people which includes around 55 million men and 110 million women. The highest rates of infertility were observed in East and South Asia, Eastern Europe. In India, there are approximately 22–23 million infertile couples, showing the urgent need to increase access to affordable, high- quality fertility care for those in need. Infertility and its treatment can negatively influence the couple’s psychological well-being which in turn could affect their fertility and treatment outcome.

Methods: This cross-sectional study included 150 couples (300 participants) who were selected through convenient sampling technique. The Fertility Problem Inventory, Dyadic Coping Inventory, and FertiQoL were used to measure infertility-related stress, dyadic coping and QoL. The Bodenmann’s dyadic coping theory was used to analyse the effects of infertility as a dyadic stressor affecting both partners and to know how they cope together for better QoL.

Objective: The purpose of this cross-sectional study was to explore the relationship between infertility-related stress and dyadic coping with quality of life (QoL) in couples with infertility issues, and verify gender differences and dyadic interactions in association between them.

Results: The study revealed that female patients perceived significantly lower levels of QoL and dyadic coping than those of husbands. There was no statistically significant difference in the infertility-related stress between wives and husbands. Husband’s infertility-related stress had actor and partner effects on their own and their wives’ QoL, while wives’ infertility-related stress only had an actor effect on their own QoL. Husbands’ dyadic coping had both actor effect and partner effects on their own and their wives’ QoL, meanwhile wives’ dyadic coping had both actor effect and partner effects on their own and their husbands’ QoL.