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VOL. 3, ISSUE 2 (2021)
Effect of maternal vitamin D on fetal bone developememnt: Prospective study
Authors
Kalaiyarasi Umapathy M S, N Hephzibah Kirubamani
Abstract
In pregnancy, the women's physiology adapts to meet additional mineral demand of developing fetus. During third trimester the fetus actively transports minerals across the placenta to maintain high circulating levels to mineralize the actively developing skeleton. Hence the maternal vitamin D insufficiency affects fetal bone health. To investigate the effect of maternal serum level of vitamin D on fetal bone development, we studied 600 pregnant prospectively. With use of high resolution 3D ultrasound, we measured femoral length and femoral splaying index at 18-22 weeks of gestation and also at 32-34 weeks of gestation along with serum vitamin D3 level. Our study revealed that lower maternal vitamin D was not related to femur length but associated with higher splaying index at second and third trimester ultra-sonograms. We categorized the study women into three groups according to serum vitamin D concentration- borderline (>50nmol/L, 59.33%), insufficient (25nmol/L - 50nmol/L, 32,67%), deficient (<25nmol/L,8%). Among them, the mean femoral splaying index increases from 0.072 (sufficient/borderline) to 0.078 (insufficient) and 0.086 (deficient). Our study suggests that maternal vitamin D can influence the fetal bone health as early as 18-20 weeks, hence measurements to improve maternal vitamin D status should be instituted from early pregnancy onwards.
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Pages:05-08
How to cite this article:
Kalaiyarasi Umapathy M S, N Hephzibah Kirubamani "Effect of maternal vitamin D on fetal bone developememnt: Prospective study ". International Journal of Gynaecology and Obstetrics Research, Vol 3, Issue 2, 2021, Pages 05-08
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