Materials and Methods: 200 pregnant women attending ANC, at ESIC MC PGIMSR HOSPITAL, Banglore who were in the 1^st trimester (up to 12weeks period of gestation) were included in the study from January 2018 to june2019. Routine laboratory investigations are done, along with the serum uric acid. (1^st trimester) serum uric acid level was measured by auto analyser. These patients were regularly followed up in the antenatal OPD once in the 4 weeks till 28 weeks then once in two weeks till there is delivery the patients who developed preeclampsia are grouped as preeclampsia Cohort. The patients who are normotensive till delivery are grouped as normal cohort. In our study, for 200, pregnant women the serum uric acid analysis was done in first trimester for prediction of preeclampsia. 92 patients were positive where uric acid level is >_4.2mg/dl of which 59(37.3%) were normotensive and 33(78.6%) were preeclamptic respectively, and remaining 108 patients were negative (where serum uric acid is _-<_ 4.2mg/dl) which among 99(62.7%) and 9(21.4%) were normotensive and preeclampsia patients respectively.so maximum number of patients were positive in preeclampsia patients that is 78.6% out of 42 patients where p value is 0.0001 which is significant

The biometric level of serum uric acid among cohort(preeclampsia) were in the mean of 4.3+- 0.81(mild), and 4.6+_0.83 for severe preeclampsia and no preeclampsia was 3.67+_0.83 by the two independent t test, both are statistically significant. Receiving operating Curve denotes optimal cut off criterion is > 4.2 for preeclampsia patients. The area under curve is 0.777 with p value of 0.0001 statistically significant.

In our study risk for both maternal and fetal complications assessed with serum uric acid positive pregnant women (>4.2mg/dl) of that P value is statistically significant in severe preeclampsia, Gestational hypertension, HELLP syndrome, mode of delivery (> by LSCS 70.7%), NICU admissions, babies of low Apgar score at 1 minute, Mean birthweight.

Conclusion: First trimester elevated uric acid was associated with later preeclampsia Assessment of uric acid is convienent and costeffective method for determination of preeclampsia and its severity and can be used as prevalent marker for risk assessment in preeclampsia(PET) or PIH.