Introduction: Infertility is defined as the inability to conceive naturally after one year of regular unprotected intercourse. Most of the time, infertility is some degree of subfertility in which 1 in 7 couples need specialist help to conceive. Subfertility can be either primary or secondary. Primary subfertility is a delay for a couple who have had no previous pregnancies; and, secondary subfertility is a delay for a couple who have conceived previously, although the pregnancy may not have been successful for example, miscarriage, and ectopic pregnancy. Though, Evaluation of the uterine cavity is mandatory when studying infertile patients and it is known that the Hysteroscopy is the gold standard for the investigation of uterine cavity, particularly when pathology is suspected. It is a safe test for the direct and accurate diagnosis of intrauterine abnormalities. It permits direct visualization of the uterine cavity, revealing the nature, location, shape, size and vascular pattern of any uterine cavity abnormalities, such as polyps, submucosal fibroids, differences in endometrial thickness and adhesions. Aim of Work: The aim of this work is to compare the findings of saline infusion sonohysterography (SIS) & office hysteroscopy (OHS) in patients with suspected uterine causes of infertility by Hystrosalpingography (HSG) or Ultrasonography (US). Cross sectional study Results:The main pathology finding in HSG and SIS were all cases were normal (80%) except in 6 cases (20%) had intrauterine polyps table the mean pathology finding diagnosed by hysteroscopy were 16 cases (53.33%) polyp. 11cases (36.7%) normal, 2cases (6.7%) with septum and only case with submoucas myoma (3.3%). Conclusion: (SIS) is a safe and relatively cheap method which allows for ruling out or confirming endometrial polyps or other endometrial defects (septum, myoma). But the accuracy and sensitivity less than the hysteroscopy. Though, Evaluation of the uterine cavity is mandatory when studying infertile patients and it is known that the Hysteroscopy is the gold standard for the investigation of uterine cavity, particularly when pathology is suspected. It is a safe test for the direct and accurate diagnosis of intrauterine abnormalities.