Objectives: To compare the efficacy & safety of continuous Oxytocin infusion & sublingual Misoprostol. Design: A prospective randomised study. Setting: Labor room of the department of Obs. & Gynaecology in V.C.S.G.G.I.M.S.& R. Srinagar in Pauri - Garhwal Uttarakhand. Method: A randomised study was conducted on 100 labor patients including both primigravida & multigravida with singleton pregnancy of 38 weeks or more; cephalic presentation & no reason for elective caesarean section. Two groups A & B were formed with 50 patients in each group. In group A labor was induced with continuous oxytocin infusion. 5 units of oxytocin was given in 500 ml. of dextrose at the rate of 10 drops/minute. The infusion rate was doubled every 20 minutes till the patient had uterine contraction lasting more than 30 seconds & with uterine contraction coming every 3 minutes or infusion rate reaching 40 drops/ min. In group B 50 micrograms of misoprostol was given sublingually; next dose was given after 6 hours. If no uterine contractions after 12 hours; a third dose was given. In either case if duration of uterine contraction exceeded 45 seconds or fetal heart irregularities occured the next dose of misoprostol was temporarily stopped. In case of oxytocin infusion i.e., group A patients the oxytocin infusion was temporarily discontinued to avoid hyper stimulation of uterus. Result: Statistically, induction of labor was better with misoprostol as compared to oxytocin. The onset of labor was quicker; patient compliance better, induction delivery interval was shorter & 3rd stage blood loss was less in patients with misoprostol induction as compared to the ones induced with oxytocin. Caesarean delivery rate was also less in misoprostol group. There was no difference in perinatal outcome.