Objective: This prospective study was done to evaluate the potency, satisfactoriness and after effects of oral misoprostol for second trimester abortion. Material and methods: This tertiary hospital based prospective study was intended on 110 women presenting to the Department of Obstetrics and Gynecology, Zanana Hospital, S.M.S. Medical college, Jaipur for second trimester abortion from 12-20 weeks during 2012-13. The women enrolled received 200 mg mifepristone, than oral misoprostol 400 microgram 3 hourly for 5 doses after 48 hours. The results were expressed in terms of induction abortion interval, dosage, success rate, satisfactoriness and after effects. Results: The mean gestational age in studied women was 17.34± 2.181 weeks. The mean gravidity in studied population was 2.13 ± 0.791. The mean induction –abortion interval was 6.44 ± 1.79 hours. The mean induction-abortion interval was shorter in multigravida i.e. 6.51 ± 1.962 hours as compare to primigravida i.e. 6.63 ± 1.457 hours. The mean induction-abortion interval was shorter with period of gestation 12-16 weeks i.e. 6.67 ± 1.966 hours as compare with gestational age 17-20 weeks with induction-abortion abortion interval of 6.84 ± 1.529 hours (p=0.4, NS). The mean dose of misoprostol required was 1003.6 ± 274.9 µg. Dose of oral misoprostol was lesser in multigravida i.e. 900.0 ± 309.1 µg as compare to primigravida i.e.1009.5 ± 277.6µg (p=0.9, NS). The mean dose of misoprostol required for gestational age 12-16 weeks was 1006.0 ± 312.7µg and 1000.0 ± 246.8 µg for gestational age 17-20 weeks (p=0.9, NS). The success rate was 100% and evacuation was needed in 3.64% cases. The mean haemoglobin was 10.16 ± 1.248 g/dl and 9.815 ± 1.138 g/dl before and after abortion. The acceptability was 100.0%. The side effect observed was pain abdomen (34.5%), nausea/vomiting (34.5%), Headache (17.3%), diarrhoea (17.3%) and fever (0.90%). Conclusion: From present study we conclude that oral misoprostol following mifepristone is highly competent and effectual method of second trimester abortion.