Background and Aims: Primary cytoreductive surgery (PDS) followed by adjuvant chemotherapy remains the standard of management for epithelial ovarian cancer (EOC). In EOC, pretreatment thrombocytosis, increased PLR and NLR were associated with advanced stage of the disease, suboptimal debulking, poor response to chemotherapy and poor survival. Haematological biomarkers like platelets and neutrophils have pro-tumor inflammatory response while lymphocytes has anti-tumor immune response. Hence, the present study aimed to predict the association of preoperative PLR and NLR with the prognosis of EOC. Materials and methods: Retrospective cohort study among 61 patients who underwent upfront surgery or upfront chemotherapy followed by interval surgery for EOC at Tata Medical Center, Kolkata from January 20015 and December 2016after obtaining ethical clearance. Clinic pathological and surgical factors retrieved from the electronic medical records were analysed and compared between the low PLR (PLR<200) vs high PLR groups (PLR³200) and low NLR (NLR<2.6) vs high NLR groups (NLR³2.6). Results: The median age of the patients was 52 yrs. Optimal cytoreduction was achieved in 91.8% patient with EOC. The median PLR and NLR were 219.3 and 4.5 respectively. The median follow up period was 16 months. 52.5% patients had recurrence till the last date of follow up and majority (68.7%) had platinum sensitive recurrence. PLR³200 and NLR³2.6 were associated with advanced stage, increased CA125 at presentation, PCI³17, SCS³8, volume of ascites³1000 mls, events (recurrence and death), but not with the surgical outcomes (optimal vs suboptimal) and survival outcomes. Conclusion: High PLR and NLR predicts poor clinicopathological and disease prognosis in patients with EOC.