Introduction: Endometriosis (E) is a chronic, benign, estrogen-dependent inflammatory disease. A debilitating disease with symptoms of dysmenorrhea, dyspareunia, and chronic pain in the pelvis (CPP). It is estimated to occurin roughly 6–10% of females. It is most common in those in their thirties and forties; however, can begin in girls as early as 8 years. Given the range of factors triggered by (E.), it must examine the quality of life (QOL) of the women affected, how the symptoms of the disease have impacted their daily life. Because of the great repercussion of (E) on different aspects of life and health of women, it is necessary to understand the confrontation mechanisms of the disease for patients as well as the impact on the quality of their lives. This can determine the improvement of care and the quality of humanization addressed to women from diagnosis tomanagement Methods: This study was conducted at at Aswan university hospital between Jan 2018- Dec 2018.This comparative study was carried out with two groups. The first group consisted of 80 women between the ages 25 and 45 years and had endometriosis. The comparison control group consisted of 80 healthy women with age ranged between 23-44 years. Each patient completed a questionnaire Short-Form 36 (SF- 36) Quality of Life Scale And assessment of pain by pain scale using visual analog scale Results: No significant difference was found between age, marital status, education level, number of coitus (weekly) between tow groups. pain levels among group( 1) 9 patients with no pain representing 11.25 %, 63 (78.75%) with mild pain and 8 (10%) Moderate pain The result of this study indicated that women with endometriosis show low quality of life compared with healthy, control subjects P value <0.01 (statistically significant). Conclusion: endometriosis is associated with diagnostic delay, reduced quality of life, and loss of work productivity and most of endometriotic patients suffering pain